Tick the feature of the sublingual route:Ĭ) A d–g is exposed more prominent liver metabolismĭ) A d–g can be administrated in a variety of dosesġ4. What is characteristic of the oral route?ī) Absorption depends on GI tract secretion and motor functionĬ) A d–g reaches the blood passing the liverĭ) The sterilization of medicinal forms is obligatoryġ3.
Which route of d–g administration is most likely to lead to the first-pass effect?ġ2. Pick out the appropriate alimentary route of administration when passage of d–gs through liver is minimized:ġ1. The reasons determing bioavailability are:ī) Amount of a substance obtained orally and quantity of intakesĬ) Extent of absorption and hepatic first-pass effectġ0. What does the term “bioavailability” mean?Ī) Plasma protein binding degree of substanceī) Permeability through the brain-blood barrierĬ) Fraction of an uncharged d–g reaching the systemic circulation following any route administrationĭ) Amount of a substance in urine relative to the initial dozeĩ. What is implied by «active transport»?Ī) Transport of d–gs trough a membrane by means of diffusionĬ) Engulf of d–g by a cell membrane with a new vesicle formationĭ) Transport against concentration gradientĨ. A hydrophilic medicinal agent has the following property:Ī) Low ability to penetrate through the cell membrane lipidsī) Penetrate through membranes by means of endocytosisĬ) Easy permeation through the blood-brain barrierħ. What kind of substances can’t permeate membranes by passive diffusion?Ħ. The main mechanism of most d–gs absorption in GI tract is:Ī) Active transport (carrier-mediated diffusion)ĥ.
Pharmacokinetics Objective Questions with Answers Pdf Download for Freshers Experienced Medical MBBS Students Pharmacokinetics Multiple choice Questions.Ī) The study of biological and therapeutic effects of d–gsī) The study of absorption, distribution, metabolism and excretion of d–gsĭ) The study of methods of new d–g developmentĬ) Influence of d–gs on metabolism processesĤ. Pharmacokinetics Multiple Choice Questions
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